The formation of mature large rRNAs from larger primary transcripts is very different in bacterial and mammalian cells. In both, cotranscription can help to assure the coordinated production of various rRNA species. However, in bacteria, processing is ordered, initiated by cleavages at double‐stranded stems which enclose the mature sequences; several cleavages are required to produce each mature terminus; and the final steps occur in polysomes, apparently linked to continued protein synthesis. In mouse cells, in contrast, cleavages generate nearly all mature (...) termini stochastically and directly, with no evidence for double‐stranded stems as cleavage signals; and processing occurs in the nucleolus, long before any new rRNA chains arrive in polysomes. Spacer sequences also serve different potnetial functions at the evolutionary extremes. In bacteria, transcribed spacer sequences are associated with different secondary structures in the pre‐rRNA compared to the mature rRNA, and these may promote ribosome formation. In mammalian cells, analyses are too premature to assign any comparable function to transcribed spacer sequences, but the non‐transcribed spacers are probably critical in the organization and replication of nucleoli, functions that are absent from bacteria. (shrink)

R.I.G Hughes offers the first detailed and accessible analysis of the Hilbert-space models used in quantum theory and explains why they are so successful.

R.I.G. Hughes presents a series of eight philosophical essays on the theoretical practices of physics. The first two essays examine these practices as they appear in physicists' treatises (e.g. Newton's Principia and Opticks ) and journal articles (by Einstein, Bohm and Pines, Aharonov and Bohm). By treating these publications as texts, Hughes casts the philosopher of science in the role of critic. This premise guides the following 6 essays which deal with various concerns of philosophy of physics such as laws, (...) disunities, models and representation, computer simulation, explanation, and the discourse of physics. (shrink)

Science and religion have been described as the “two dominant forces in our culture”. As such, the relation between them has been a matter of intense debate, having profound implications for deeper understanding of our place in the universe. One position naturally associated with scientists of a materialistic outlook is that science and religion are contradictory, incompatible worldviews; however, a great deal of recent literature criticises this “conflict thesis” as simple-minded, essentially ignorant of the nature of religion and its philosophical (...) and theological underpinnings. In this first part of a two-part article, I set out the wide-ranging background required for a proper understanding of the debate as a preliminary for the second part, in which Ian Barbour ’s influential four-fold typology of science-religion relations is critically assessed, leading to the conclusion that the conflict model is not to be so easily dismissed. (shrink)

Group size is a function of relative neocortical volume in nonhuman primates. Extrapolation from this regression equation yields a predicted group size for modern humans very similar to that of certain hunter-gatherer and traditional horticulturalist societies. Groups of similar size are also found in other large-scale forms of contemporary and historical society. Among primates, the cohesion of groups is maintained by social grooming; the time devoted to social grooming is linearly related to group size among the Old World monkeys and (...) apes. To maintain the stability of the large groups characteristic of humans by grooming alone would place intolerable demands on time budgets. It is suggested that (1) the evolution of large groups in the human lineage depended on the development of a more efficient method for time-sharing the processes of social bonding and that (2) language uniquely fulfills this requirement. Data on the size of conversational and other small interacting groups of humans are in line with the predictions for the relative efficiency of conversation compared to grooming as a bonding process. Analysis of a sample of human conversations shows that about 60% of time is spent gossiping about relationships and personal experiences. It is suggested that language evolved to allow individuals to learn about the behavioural characteristics of other group members more rapidly than is possible by direct observation alone. (shrink)

Data from various settings suggest that there is an upper limit of about four on the number of individuals who can interact in spontaneous conversation. This limit appears to be a consequence of the mechanisms of speech production and detection. There appear to be no differences between men and women in this respect, other than those introduced by women’s lighter voices.

R.I.G. Hughes presents a series of eight philosophical essays on the theoretical practices of physics. The first two essays examine these practices as they appear in physicists' treatises and journal articles. By treating these publications as texts, Hughes casts the philosopher of science in the role of critic. This premise guides the following six essays which deal with various concerns of philosophy and physics such as laws, disunities, models and representation, computer simulation, explanation, and the discourse of physics.

Data on the number of adults that an individual contacts at least once a month in a set of British populations yield estimates of network sizes that correspond closely to those of the typical “sympathy group” size in humans. Men and women do not differ in their total network size, but women have more females and more kin in their networks than men do. Kin account for a significantly higher proportion of network members than would be expected by chance. The (...) number of kin in the network increases in proportion to the size of the family; as a result, people from large families have proportionately fewer non-kin in their networks, suggesting that there is either a time constraint or a cognitive constraint on network size. A small inner clique of the network functions as a support group from whom an individual is particularly likely to seek advice or assistance in time of need. Kin do not account for a significantly higher proportion of the support clique than they do for the wider network of regular social contacts for either men or women, but each sex exhibits a strong preference for members of their own sex. (shrink)

The fierce propaganda campaign against the CPSU and other Marxist-Leninist parties developed in the 1960s by the Mao Tse-tung group in China confronted the international communist movement with the fact that a new front in the ideological struggle had come into being. The significance of this struggle is defined by the fact that the matter at issue is what constitutes a contemporary, truly scientific interpretation of the principles of revolutionary theory, and the determination of the future of socialism and communism.

I argue that, while Finlay et al, are correct to suggest that there are developmental regularities (or constraints) acting on brain component evolution, they are incorrect to infer from this that a developmental explanation necessarily implies that structural changes preceded functional use. Developmental and functional (adaptationist) explanations are complementary, not alternatives.

An awareness of the special role of the time factor in the organization and functioning of living systems and achievements in the study of biological clocks have posed the problem of the role of the time factor in relation to the whole concept of reflection of reality. The study of this role is one of the extremely timely and fundamental tasks of scientific theory. The problem of "reflection and time" has essentially become one of the main lines of general theoretical (...) attempts to understand the structure of space and time and the unity of the world, the principle of the universal interrelatedness and mutual dependence among objects and phenomena, and the essence of the reflective activity of living systems. (shrink)

Clark & Thornton take issue with my claim that parity is not a generalisation problem, and that nothing can be inferred about back-propagation in particular, or learning in general, from failures of parity generalisation. They advance arguments to support their contention that generalisation is a relevant issue. In this continuing commentary, I examine generalisation more closely in order to refute these arguments. Different learning algorithms will have different patterns of failure: back-propagation has no special status in this respect. This is (...) not to deny that a particular algorithm might fortuitously happen to produce the “intended” function in an parity-generalisation task. (shrink)

Purpose. The article analyzes the role of such a phenomenon as tolerance in a partnership between a man and a woman, emphasizing its importance and necessity in their relations. The purpose of the study is to estimate the role of the tolerance phenomenon in the process of gender partnership. Theoretical basis. The works of domestic and foreign scientists contributed to estimate the function of tolerance during communication, cooperation and co-creation. In this paper the methodology of E. Fromm and N. Khamitov’s (...) metaanthropology is used. Originality. It was proved that the success of a gender partnership depends on how tolerant its participants are to each other. Besides this, it has been established that tolerance is the main criterion for gender partnership. The idea of tolerance is considered as the way to fruitful development of human relations. For the first time it has been determined that gender partnership can be manifested on the ordinary, frontier and metafrontier levels of human existence. Tolerance has its own specifics and a manifestation on each of them. Conclusions. Metaanthropology has helped to estimate the role of tolerance among men and women in the partnership process. So, it can be stated that tolerance is a basis for gender partnership that harmonizes the relationship among a man and a woman and makes them egalitarian. Only on the metafrontier level of human being tolerance can be manifestation of individual integrity. Sincere, open interaction and creative work with Other are formed on this foundation. Thus, gender partnership with inexhaustible, complementary potential is the vector of development of human relations. (shrink)

In the preceding Part 1 of this two-part paper, I set out the background necessary for an understanding of the current status of the debate surrounding the relationship between science and religion. In this second part, I will outline Ian Barbour’s influential four-fold typology of the possible relations, compare it with other similar taxonomies, and justify its choice as the basis for further detailed discussion. Arguments are then given for and against each of Barbour’s four models: conflict, independence, integration and (...) dialogue. In contradiction of the recent trend to dismiss the conflict model as overly “simplistic”, I conclude that it is the clear front-runner. Critical examination reveals that theology (the academic face of religion) typically proceeds by first affirming belief in God and then seeking rationalisations that protect this belief against contrary evidence. As this is the very antithesis of scientific endeavour, the two disciplines are in unavoidable and irreconcilable conflict. (shrink)

John Searle attempts to show through a consideration of promising that at least some ‘ought’ statements can be derived from ‘is’ statements. He thinks that you can determine on purely factual grounds that a person has made a promise, and that it follows logically from the statement that a person has made a promise that he has at least a prima facie obligation to do the thing he promised to do. I agree with but not with.

Книга предназначена для философов, социологов, историков, студентов гуманитарных специальностей и всех интересующихся панорамой развития русской историко-философской мысли.

Locke is the first English philosopher to be considered in this series, and that fact of itself is worthy of attention. Philosophy, of course, like science, knows no frontiers and no national boundaries. Yet it is true to say that Locke’s contribution to philosophy is typically and peculiarly English. His moderation, his emphasis upon experience, his tolerant spirit of compromise, his dislike of mystical extravagance and of metaphysical speculation, even that elusive quality of his which people call his “common sense”, (...) are English traits. His very defects, illogicality leading to inconsistency and an awkward disorderliness of thought so abhorrent to the. (shrink)